HDL modification

HDL modification by secretory phospholipase A(2) promotes scavenger receptor class B type I interaction and accelerates HDL catabolism.

During inflammatory states plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) are reduced. Secretory group IIa phospholipase A(2) (sPLA(2)) is a cytokine-induced acute-phase enzyme associated with HDL. Transgenic mice overexpressing sPLA(2) have reduced HDL levels. Studies were performed to define the mechanism for the HDL reduction in these mice. HDL is...

Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112

RATIONALE CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL). OBJECTIVE To explore the mechanisms by which the formation of small HDL particles is induced by CSL112. METHODS AND RESULTS Infusion of CSL112 into humans caused elevation of 2 small diameter HDL fractions and 1 large diameter...

Diet modification alters plasma HDL cholesterol concentrations but not the transport of HDL cholesteryl esters to the liver in the hamster.

These studies were undertaken to investigate the mechanism whereby diet modification alters the plasma concentration of high density lipoprotein (HDL) cholesteryl ester and apoA-I and to determine whether diet-induced alterations in circulating HDL levels are associated with changes in the rate of reverse cholesterol transport. Rates of HDL cholesteryl ester and apoA-I transport were measured i...

HDL Cholesterol Story Is Dead: Long Live HDL!

It is a great irony that the earliest discovered lipoprotein is also the least well understood. In 1929, Michel Machebouef at the Pasteur Institute in Paris, using salt precipitation techniques, isolated a lipoprotein particle from horse serum composed predominantly of an a-globulin (59%), which we now know to be high-density lipoprotein (HDL) (1). Epidemiological studies in the 1970s, includin...

HDL Function: Redefining the HDL Hypothesis for the 21 Century